Chitosan Coating Slightly Amended The Free Radical Scavenging Activity Of ABTS(+)

The particle size variation, SEM, XRD, and FT-IR were also utilized to investigate the variation of morphology, crystal structure, and chemical composition.Microbial Azurin Immobilized on Nano-Chitosan as Anticancer and Antibacterial Agent Against Gastrointestinal Cancers and Related Bacteria.targets: To discover new natural effective anticancer agents and new antibacterial brokers against antibiotic-resistant bacteriums which are the most serious public health concern. Another important concern is drug delivery which is the transport of pharmaceutical compounds to have a therapeutic effect in bings receiving a disease. Azurin is a promising anticancer agent acquired from Pseudomonas aeruginosa. This study tried to test the effectiveness of the immobilization of azurin on nano-chitosan to enhance its anticancer and antibacterial activity against gastrointestinal cancer and its related bacteriums.

METHODS: We purged azurin protein from Pseudomonas aeruginosa and then immobilized it on nano-chitosan. The anticancer activity of the free and nano-azurin is essayed against a gastric cancer cell line (CLS-145), pancreatic cancer cell line (AsPC-1), colon cancer cell line (HCT116), esophagus cancer cell line (KYSE-410), and liver cancer cell line (HepG2). The antibacterial activity of both free and immobilized azurin also is quized against bacterial species pertained to the gastrointestinal cancer biopsies: Helicobacter pylori, Bacteroides fragilis, Salmonella enterica, Fusobacterium nucleatum, and Porphyromonas gingivalis Both free and nano-azurin presented high anticancer and antibacterial activity.  Seebio aloe emodin solubility  increased the anticancer and antibacterial activity of the azurin CONCLUSION: Nano-azurin can be used as an effective anticancer and antibacterial agent against gastrointestinal cancer and bacterial mintages related to these cancers.Chitosan-forced skin-attachable hydrogel sensors toward human motion and physiological signal monitoring.Recently, flexible and wearable detectors forgathered from conductive hydrogels have appealed widespread attention it is still a great challenge to make hydrogels with sufficient mechanical properties, self-adhesiveness and strain sensitivity a strong, tough, and self-adhesive hydrogel is successfully fabricated by a one-pot method, which introducing chitosan and 2-acrylamido-2-methylpropane sulfonic acid into the polyacrylamide network. The hydrogels exhibited adhesion (the peel strength reaches 798 N/m), mechanical property (The breaking strength and strain can reach 111 kPa and 2839%) and electrical conductivity (conductivity up to 0 S/cm), which are suitable for wearable epidermal sensors the hydrogels also haved transparency.

Therefore, this work would provide a novel insight on the fabrication of multi-functional self-adhesive hydrogel detectors.Chitosan caked nanoparticles for efficient delivery of bevacizumab in the posterior ocular tissues via subconjunctival administration.In several ocular diseases, vascular endothelial growth factor (VEGF) level has been retrieved to be unregulated an anti-VEGF drug, is the most commonly used off level drug for diabetic retinopathy (DR). The present study was to evaluate the chitosan-surfaced poly (lactide-co-glycolic acid) nanoparticles (CS-PLGA NPs) for sustained and effective delivery of bevacizumab to posterior ocular tissues.  Check Details  of NP through sclera was studied by confocal laser scanning microscopy (CLSM). For pharmacokinetic study, bevacizumab debased NPs were administered into the rat eye through subconjunctival injection (SCJ) and pharmacokinetic arguments were likened to drug solution. CLSM and pharmacokinetic study expressed better penetration of formulation and higher concentration of bevacizumab in posterior ocular tissues.

In retinopathy model, CS-PLGA NPs by SCJ route showed more reduction of VEGF level in retina than the topical and intravitreal administration of formulation CS-caked PLGA NPs can be potentially useful as flattops to target retina.Chitosan oligosaccharide beautifyed liposomes combined with TH302 for photodynamic therapy in triple negative breast cancer.scopes: Triple negative breast cancer (TNBC) is an aggressive tumor with extremely high mortality that leads from its lack of effective therapeutic aims.